Inhibition of CYP2D6 by mitragynine CSV JSON

In Vitro Enzyme Inhibition Experiment

Inhibition of CYP2D6 by mitragynine

Inhibition was detected.  Cutoff used — High probability of interaction if their IC50 values are less than 1 µM. If IC50 values are between 1 and 10 µM, they have moderate possibility in interaction. Low drug-drug interactions if their IC50 values are greater than 10 µM.



  • CYP2D6 4173631

Recombinant expression system Baculovirus-insect cells
Cytochrome B5 No


IC50 values from Table 1, Ki values from Table 3

% enzyme inhibition versus precipitant concentration:
Values estimated from Figure 2. In some cases, SEM could not be estimated from the provided figure.

0.02 μM: 43 ± Unknown%
0.2 μM: 60 ± Unknown%
2 μM: 77 ± Unknown%
20 μM: 86 ± Unknown%
200 μM: See above data

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

Mitragynine was isolated in-house. This assay was carried out using the P450-Glo™ Screening Systems from Promega, USA.

Commercially available

65 min

NADPH regenerating system

Not available


0.02-200 µM