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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-RPqAvQ Cannabis (Cannabis sativa) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes 6-alpha-OH-CBD-quinidine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2D6
cannabidiol 6α-oh-cannabidiol quinidine
NPDI-FnVAqw Kratom (Mitragyna speciosa) Evaluation of selected Malaysian medicinal plants on phase I drug metabolizing enzymes, CYP2C9, CYP2D6 and CYP3A4 activities in vitro POS. CONTROL: Inhibition of CYP2D6 by quinidine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
ethylene glycol ester of luciferin 6’methyl ether (luciferin me-ege) luciferin quinidine
NPDI-d0noGQ Kratom (Mitragyna speciosa) Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities POS. CONTROL: Inhibition of CYP2D6 by quinidine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
ethylene glycol ester of luciferin 6’methyl ether (luciferin me-ege) luciferin quinidine
NPDI-ye4dPw Kratom (Mitragyna speciosa) The inhibitory effects of mitragynine on P-glycoprotein in vitro Down regulation of P-gp mRNA expression by 1 µM quinidine In Vitro Transporter Induction positive — In Vitro Transporter Down Regulation
  • P-gp (ABCB1)
quinidine
NPDI-4AITQg Kratom (Mitragyna speciosa) Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids Control Positive Inhibition for CYP2D6 In Vitro Enzyme Inhibition (Control experiment) positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan quinidine
NPDI-WL-VKw Kratom (Mitragyna speciosa) The inhibitory effects of mitragynine on P-glycoprotein in vitro Control inhibition of P-gp digoxin transport by quinidine In Vitro Transporter Inhibition (Control experiment) positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
digoxin quinidine

Compound information from external resources

Resource Identifier
Google search LOUPRKONTZGTKE-LHHVKLHASA-N