Control inhibition of P-gp digoxin transport by quinidine CSV JSON

In Vitro Transporter Inhibition Experiment

Control inhibition of P-gp digoxin transport by quinidine

Inhibition was detected.  Cutoff used —

(not provided)

digoxin 1326303

quinidine

  • P-gp (ABCB1)

Cell system Caco-2 cells

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

Cell Culture Conditions

100000 cells / cm^2 per insert

Transwell® polycarbonate membrane cell culture insert

21

Viability and Function

350 - 600 Ωcm^2

Assay Conditions

72 h

10 µM

10 µM