- Natural product: Kratom (Mitragyna speciosa)
- Associated study: The inhibitory effects of mitragynine on P-glycoprotein in vitro
In Vitro Transporter Induction Experiment
Down regulation of P-gp mRNA expression by 1 µM quinidine
Down Regulation was detected. Cutoff used —
p < 0.05 compared with control
- P-gp (ABCB1)
Cell system Caco-2 cells
Results
% Inhibition mean taken from text. SD estimated from Figure 3b.
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
mRNA expression
1 µM
72 h
Reverse transcription-quantitative real-time PCR