Inhibition of CYP2C9 by M. speciosa methanolic extract CSV JSON

In Vitro Enzyme Inhibition Experiment

Inhibition of CYP2C9 by M. speciosa methanolic extract

Negligible Inhibition was detected.  Cutoff used — Not specified.


  • CYP2C9 4309227

Recombinant expression system Baculovirus-insect cells
Cytochrome B5 Not available


IC50 not determined due to the less than 50% of inhibition.

% enzyme inhibition versus precipitant concentration:
Values estimated from Figure 1d. In some cases, SEM could not be estimated from the provided figure.

0.01 µg/mL: 20 ± Unknown%
0.1 µg/mL: 18 ± Unknown%
1 µg/mL: 22 ± 6%
10 µg/mL: 23 ± 6%
100 µg/mL: 26 ± 2%
1000 µg/mL: See above data

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

M. speciosa methanolic extract was prepared in-house from the leaves of the plant. This assay was carried out using the P450-Glo™ Screening Systems from Promega, USA.

The minus-P450 wells (using luciferin-free water) were negative controls.

Commercially available

100 µL

50 min

NADPH regenerating system

Not available

Not available

0.01-1000 µg/mL