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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-m-NOOw Kratom (Mitragyna speciosa) Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities Enzyme kinetics of CYP2C9 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • CYP2C9
6’deoxyluciferin (luciferin h) luciferin
NPDI-v2Z25g Kratom (Mitragyna speciosa) Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities POS. CONTROL: Inhibition of CYP2C9 by sulfaphenazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
6’deoxyluciferin (luciferin h) luciferin sulfaphenazole
NPDI-1tFkCA Kratom (Mitragyna speciosa) Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities Inhibition of CYP2C9 by mitragynine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
6’deoxyluciferin (luciferin h) luciferin mitragynine
NPDI-H6ZqbA Kratom (Mitragyna speciosa) Evaluation of selected Malaysian medicinal plants on phase I drug metabolizing enzymes, CYP2C9, CYP2D6 and CYP3A4 activities in vitro POS. CONTROL: Inhibition of CYP2C9 by sulfaphenazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
6’deoxyluciferin (luciferin h) luciferin sulfaphenazole
NPDI-jkwBEg Kratom (Mitragyna speciosa) Evaluation of selected Malaysian medicinal plants on phase I drug metabolizing enzymes, CYP2C9, CYP2D6 and CYP3A4 activities in vitro Inhibition of CYP2C9 by M. speciosa methanolic extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C9
6’deoxyluciferin (luciferin h) luciferin methanolic extract of kratom