Cat's-claw (Uncaria tomentosa)

Full Name: Uncaria tomentosa (Willd. ex Schult.) DC.
Kingdom: Plantae
Order: Gentianales
Family Name: Rubiaceae
Latin Binomial: Uncaria tomentosa
Common Names: Cat's-claw

Natural Product Information From GSRS

Resource Identifier
= Induction
= Inhibition
= No overall effect

Published in vitro enzyme experiments

pteropodine cat's claw extract isopteropodine mitraphylline
CYP3A4
ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-bb32sA Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Pteropodine on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam pteropodine
NPDI-x4WmyA Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Isopteropodine Effect on CYP3A4 mRNA Expression In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • CYP3A4
isopteropodine
NPDI-7DK5Zg Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Pteropodine Effect on CYP3A4 mRNA Expression In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • CYP3A4
pteropodine
NPDI-H4kVpw Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Isopteropodine Effect on PXR Activation In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
isopteropodine
NPDI-nRt2ng Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/500 Extracts on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam cat's claw extract
NPDI-h8CxDA Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/1000 Extracts on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam cat's claw extract
NPDI-SRsArQ Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/100 Extracts on PXR Activation In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
cat's claw extract
NPDI-CL8itw Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/500 Extracts on PXR Activation In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
cat's claw extract
NPDI-DbntYQ Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/1000 Extracts on PXR Activation In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
cat's claw extract
NPDI-Hr_w8g Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/2500 Extracts on PXR Activation In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
cat's claw extract
NPDI-1G7o6Q Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/5000 Extracts on PXR Activation In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
cat's claw extract
NPDI-SZr2oA Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Isopteropodine on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam isopteropodine
NPDI-h2rgNA Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Mitraphylline Effect on PXR Activation In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
mitraphylline
NPDI-McqRuA Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Mitraphylline on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam mitraphylline
NPDI-7n3MdQ Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/7500 Extracts on PXR Activation In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
cat's claw extract
NPDI-hg991g Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/5000 Extracts on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam cat's claw extract
NPDI-UbcSjQ Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/5000 Extracts on CYP3A4 mRNA Expression In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • CYP3A4
cat's claw extract
NPDI-t1K-qQ Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Mitraphylline Effect on CYP3A4 mRNA Expression In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • CYP3A4
mitraphylline
NPDI-4qI8gg Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Pteropodine Effect on PXR Activation In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
pteropodine
NPDI-NxBuuA Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/2500 Extracts on CYP3A4 Activity In Vitro Enzyme Induction positive — In Vitro Enzyme Induction
  • CYP3A4
midazolam 1'-hydroxymidazolam cat's claw extract
NPDI-A3--xw Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/1000 Extracts on CYP3A4 mRNA Expression In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • CYP3A4
cat's claw extract
NPDI-TVYo2w Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/500 Extracts on CYP3A4 mRNA Expression In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • CYP3A4
cat's claw extract
NPDI-lS8eJw Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Metabolomic Profiling of Cat's Claw Extracts Characterization of Material
NPDI-VOj3Ug Cat's-claw (Uncaria tomentosa) Identification of PXR activators from Uncaria tomentosa (Cat’s Claw) Cat's Claw 1/2500 Extracts on CYP3A4 mRNA Expression In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • CYP3A4
cat's claw extract