clinical goldenseal - furosemide experiment CSV JSON

In Vivo Interaction Study

clinical goldenseal - furosemide experiment

No Effect (based on bioequivalence limits) was detected.

furosemide 956874

goldenseal root extract

  • OAT1 (SLC22A6)
  • OAT3 (SLC22A8)

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

Probe cocktail study
Fixed-sequence

Population

Healthy volunteers

16

8 male and 8 female (non-lactating women )

Pharmacokinetic (PK) Sampling Information

24, 48, 72, and 96 hours after cocktail administration

Drug or Natural Product Administration

Object Administration — furosemide

Oral

Furosemide (10 mg/mL solution; West-ward Pharmaceuticals Corp., Eatontown, NJ), metformin (500 mg/5 mL solution; Ranbaxy Pharmaceuticals, Inc., Jacksonville, FL), rosuvastatin (10 mg tablet; Camber Pharmaceuticals Inc., Piscataway, NJ), and midazolam (2 mg/mL syrup; West-ward Pharmaceuticals Corp.)

1 mg furosemide, 50 mg metformin, 10 mg rosuvastatin, and 2.5 mg midazolam

single dose

once

Precipitant Administration — goldenseal root extract

Oral

capsule

3 g

1 g every 4 hours

3 times

Natural Product Characteristics

Now Foods, Bloomingdale, IL

2019