- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4 phenotypes
In Vivo Interaction Study
No Effect (based on bioequivalence limits) was detected.
- CYP1A2 4312402
|Sample||Compound measured||Value||Measurement||Study sequence||Additional information||N replicates|
Probe cocktail study
CYP2D6 ultra-rapid metabolizer
(6 females) (age, mean ± SD = 24 ± 3.0 years; weight, 69.3 ± 14.2 kg)
Did not use botanical dietary supplements or non-prescription/prescription medications aside from oral contraception in the female group, which they continued.
All females had a negative prenancy test at baseline
1 and 6 hours
Drug or Natural Product Administration
twice in 28 day trial
three times daily
Wild Oats Markets, Inc. Boulder, CO.
Pharmacodynamics (PD) & Adverse Events
General disorders and administration site conditions 35800000
Headache (4 of 12 subjects) and nausea (3 of 12 subjects)