Intravenous Metformin/Oral Inhibitor Mouse Study - Imatinib CSV JSON

In Vivo Interaction Study

Intravenous Metformin/Oral Inhibitor Mouse Study - Imatinib

No Effect (based on bioequivalence limits) was detected.

metformin 1503297

imatinib

Results

Control:
-AUCR (ratio of AUC0-12h in presence of test article to vehicle; values represented as geometric means with 90% CI): N/A
Test: 
-AUCR (ratio of AUC0-12h in presence of test article to vehicle; values represented as geometric means with 90% CI): 1.20 (0.97-1.50)

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

Blood was used for LC-MS analysis.

Single dosing

Population

Males

FVB

7 per test group

The form has been tweaked for the mice study.
Study population: mice
Study population phenotype: Jackson laboratory (Bar Harbor, Maine)

Pharmacokinetic (PK) Sampling Information

0.083, 0.25, 0.5, 1, 2, 4, 8, and 12 h

None

Drug or Natural Product Administration

Object Administration — metformin

Intravenous

Liquid

Metformin (10 mg/kg)

Single dose of goldenseal and imatinib administered by oral gavage at 10 ml/kg for both goldenseal and metformin. Metformin was administered by retroorbital injection.

Once

Precipitant Administration — imatinib

Oral

N/A

Imatinib (100 mg/kg)

Single dose of goldenseal and imatinib administered by oral gavage at 10 ml/kg for both goldenseal and metformin. Metformin was administered by retroorbital injection.

Once

Natural Product Characteristics

Goldenseal

Yes - sent to Clarke lab by Dr. Oberlies at UNCG

N/A

Pharmacodynamics (PD) & Adverse Events

N/A

N/A

N/A