Goldenseal (Hydrastis canadensis)
LC-MS metablomics and composite score analysis [1,2] was used to compare the chemical composition of 35 commercial H. canadensis samples. A single sample (dried Hydrastis canadensis room material, arbitrarily identified as GS-16) was chosen for use in pharmacology studies based on its similarity to authentic reference standards and to other commercially used goldenseal supplements.
1. Joshua J. Kellogg, Olav M. Kvalheim, Nadja B. Cech, Composite score analysis for unsupervised comparison and network visualization of metabolomics data,Analytica Chimica Acta, Volume 1095, 2020, Pages 38-47, ISSN 0003-2670, https://doi.org/10.1016/j.aca.2019.10.029.
2. Wallace ED, Oberlies NH, Cech NB, Kellogg JJ. Detection of adulteration in Hydrastis canadensis (goldenseal) dietary supplements via untargeted mass spectrometry-based metabolomics. Food Chem Toxicol. 2018;120:439-447. doi:10.1016/j.fct.2018.07.033.
1 . Goldenseal Metabolomics Experiment (id=NPDI-ZFajng)
LC-MS metabolomics profiling was employed to compare the chemical composition 35 commercial H. canadensis samples.
|Sample||Compound measured||Value||Measurement||Study sequence||Additional information||N replicates|
Select the number of dimensions to view in the PCA plot. Each dimension corresponds with a principal component selected.
Data points represent the following samples (click to show/hide):
Click any dot in the plot to get more information about that particular data point in the
table below the plot.
In the 3-D plot, you can double click anywhere in the space to focus the camera on that particular point and scroll to zoom in and out