- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents
In Vitro Enzyme Inhibition Experiment
1A2 Inhibition by Ethanolic GS Extract
Negligible Inhibition was detected. Cutoff used — not specified
- CYP1A2 4312402
Cell fraction Pooled human liver microsomes -7999662
Results
Fig 1 Estimate at 20 μM
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
In-house preparation
HHM-247 and HHM-258
15 min
NADPH
10 min
No NADPH with precipitant
1 or 20 μM