buprenorphine
InChIKey: RMRJXGBAOAMLHD-IHFGGWKQSA-N

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Compound information managed by NaPDI


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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-pMOhyQ Kratom (Mitragyna speciosa) Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5’- diphospho-glucuronosyltransferase isoforms Inhibition of UGT in human liver microsomes by buprenorphine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide buprenorphine
NPDI-3eovVg Kratom (Mitragyna speciosa) Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5’- diphospho-glucuronosyltransferase isoforms Negligible inhibition of UGT1A1 by buprenorphine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • UGT1A1
4-methylumbelliferone 4-methylumbelliferone glucuronide buprenorphine
NPDI-ZTY8Qw Kratom (Mitragyna speciosa) Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5’- diphospho-glucuronosyltransferase isoforms Inhibition of UGT2B7 by buprenorphine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT2B7
4-methylumbelliferone 4-methylumbelliferone glucuronide buprenorphine

Compound information from external resources

Resource Identifier
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