Mitraphylline p-gp transport kinetics MDCK CSV JSON

In Vitro Transporter Kinetics Experiment

Mitraphylline p-gp transport kinetics MDCK

Transport Activity was detected.  Cutoff used — ER of 2

mitraphylline

  • P-gp (ABCB1)

Transfected / siRNA knock-out / injected cells MDCK transfected cells

Results

p<0.001
ER for 10 uM was 5.9 also significant
(Table 4)

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

Cell Culture Conditions

70 000 cells/well

200 μL

Transwell

2

30–42

Viability and Function

>1100 ohm/cm2

TEER measurements and Ly permeability.

Assay Conditions

120 min

37 deg C

7.4

5,10 uM