CBD Effect on Stiripentol Concentrations CSV JSON

Natural product: Cannabis (Cannabis sativa)
Associated study: Drug Approval Package: Epidiolex (Cannabidiol)

In Vivo Interaction Study

CBD Effect on Stiripentol Concentrations

Increased systemic exposure was detected.

Object compound

stiripentol

Precipitant

cannabidiol

Study GWEP1543

Results

When CBD was combined with stiripentol there was a minor increase in Cmax and AUCtau; 1.28 and 1.55-fold, respectively.

Sample	Compound measured	Value	Measurement	Study sequence	Additional information	N replicates

Experimental Conditions

Study design

Fixed-sequence
Parallel
Multiple dosing

Population

Demographic characteristics

Females
Healthy volunteers
Males

Number of subjects

Population additional information

Arm 1, Group 3

Drug or Natural Product Administration

Object Administration — stiripentol

Administration route

Oral

Formulation

Not stated

Total daily dose

1500 mg

Interval/frequency

750 mg BID

Duration

14 days

Precipitant Administration — cannabidiol