Valproic Acid Effect on Cannabidiol Metabolites CSV JSON

Natural product: Cannabis (Cannabis sativa)
Associated study: Drug Approval Package: Epidiolex (Cannabidiol)

In Vivo Interaction Study

Valproic Acid Effect on Cannabidiol Metabolites

No Effect (based on bioequivalence limits) was detected.

Object compound

cannabidiol

Precipitant

valproic acid

Study GWEP1543

Results

Sample	Compound measured	Value	Measurement	Study sequence	Additional information	N replicates

Experimental Conditions

Study design

Fixed-sequence
Parallel
Multiple dosing

Population

Demographic characteristics

Females
Healthy volunteers
Males

Number of subjects

Population additional information

Arm 2, Group 6

Drug or Natural Product Administration

Object Administration — cannabidiol

Administration route

Oral

Formulation

Solution

Total daily dose

1500 mg

Interval/frequency

750 mg BID

Duration

9 days

Precipitant Administration — valproic acid

Administration route

Oral

Formulation

Not specified

Total daily dose

1000 mg

Interval/frequency

500 mg BID

Duration

9 days

Natural Product Characteristics

Year sourcing was completed