- Natural product: Cannabis (Cannabis sativa)
- Associated study: Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse
In Vitro Enzyme Inhibition Experiment
CBD on ethanol glucuronidation
Inhibition was detected. Cutoff used — Not specified
- UGT
Cell system Human cryopreserved hepatocytes
Results
%inhibition estimated from Fig 4 at 15 mg/L.
Ki (3.1 mg/L) from Fig 5.
IC50 (1.17 mg/L) and Ki converted from mg/L to µg/mL
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
In-house preparation
100 μL
45 min
MgCl2
UDPGA
25 mM
5 min
No NADPH with no precipitant
0, 5, 10,15 mg/L