CBD on ethanol glucuronidation CSV JSON

In Vitro Enzyme Inhibition Experiment

CBD on ethanol glucuronidation

Inhibition was detected.  Cutoff used — Not specified

ethanol

cannabidiol (cbd)

ethyl glucuronide

  • UGT

Cell system Human cryopreserved hepatocytes

Results

%inhibition estimated from Fig 4 at 15 mg/L.
Ki (3.1 mg/L) from Fig 5.
IC50 (1.17 mg/L) and Ki converted from mg/L to µg/mL

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

In-house preparation

100 μL

45 min

MgCl2

UDPGA

25 mM

5 min

No NADPH with no precipitant

0, 5, 10,15 mg/L