- Natural product: Kratom (Mitragyna speciosa)
- Associated study: Evaluation of the Effects of Mitragyna speciosa Alkaloid Extract on Cytochrome P450 Enzymes Using a High Throughput Assay
In Vitro Enzyme Inhibition Experiment
Mitragynine inhibition of CYP1A2
Inhibition was detected. Cutoff used —
Not specified
- CYP1A2 4312402
Recombinant expression system Not available
Cytochrome B5 Not available
Results
Furafylline is used as the positive control
(Table 2, Figure 2)
Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
---|
Experimental Conditions
0.5 pmol/well
Commercially available
20 min
NADPH regenerating system