Inhibition of ABCC1 by Cannabidiol CSV JSON

In Vitro Transporter Inhibition Experiment

Inhibition of ABCC1 by Cannabidiol

Inhibition was detected.  Cutoff used —

NA

vincristine

cannabidiol

  • ABCC1

Cell system Human ovarian carcinoma cell line

Results

Measurements show 50% reduction in transport using increase in intracellular accumulation based on % of parent concentration.

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

incubation time with two phases, cells and natural products for 30 min and then with Vincristine for another 90 min

Cell Culture Conditions

24 well plates

Assay Conditions

90 min

37 C

1 µg/ml

2, 10, 50 and 100 µM