In Vitro Enzyme Inhibition Experiment

Inhibition of CYP2A1 by Licochalcone A

Inhibition was detected.  Cutoff used —

> 25 µg/ml

phenacetin 19033710

licochalcone a

acetaminophen 1125315

  • CYP1A2 4312402

Cell fraction Pooled human liver microsomes -7999662

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.2 mg/mL

10 min

NADPH

100 µM

11 concentrations from 0.005–250 μg/mL