Mitragynine inhibition of CYP3A4 CSV JSON

In Vitro Enzyme Inhibition Experiment

Mitragynine inhibition of CYP3A4

Inhibition was detected.  Cutoff used —

Not specified

7-benzyloxy-4-(trifluoromethyl)-coumarin

mitragynine

7-hydroxy-4-(trifluromethyl)-coumarin

  • CYP3A4 4306811

Recombinant expression system Not available
Cytochrome B5 Not available

Results

Ketoconazole was used as the positive control.
(Table 2, Figure 2)

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

1 pmol/well

30 min

NADPH regenerating system