- Natural product: Ceylon cinnamon (Cinnamomum verum)
- Associated study: Mechanisms of Herb-Drug Interactions Involving Cinnamon and CYP2A6: Focus on Time-Dependent Inhibition by Cinnamaldehyde and 2-Methoxycinnamaldehyde
In Vitro Enzyme Inhibition Experiment
Evaluation of Time Dependent Inhibition of CYP2A6 by 2-methoxycinnamaldehyde (Model 3)
Inhibition was detected. Cutoff used —
No cutoff was mentioned by the research organization.
- CYP2A6 4309826
Cell fraction Pooled human liver microsomes -7999662
This experiment refers to the EII-PI-M-IL Model 3 in Table 3.
Results
*not specified in paper whether geometric or arithmetic mean was used - assumed geometric
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
1 uM
Commercially available
10 uL
0-90 min
NADPH regenerating system
Not available
Not available
75 uM
No NADPH with precipitant
190 uL
10 min
0, 5, 10, 20, 40, 80, 100, 125, 150, 175, 200, 250 uM