CBD Effect on N-desmethylclobazam Concentrations CSV JSON

In Vivo Interaction Study

CBD Effect on N-desmethylclobazam Concentrations

Increased systemic exposure was detected.

n-desmethylclobazam

cannabidiol (cbd)

From page 109 of "Clinical Pharmacology Biopharmaceutics Review"

Results

From page 109

Units for these values are NOT means but are instead a ratio of day 33 values:day 1 values

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

Double-blind
Placebo-controlled
Randomized crossover
Multiple dosing

Population

Females
Males
Patients

CYP2C19 intermediate metabolizer
CYP2C19 rapid metabolizer
CYP2C19 ultra-rapid metabolizer

20

"A total of 20 patients were randomized to receive 20 mg/kg/day of CBD or placebo on a 4:1 basis."

Pharmacokinetic (PK) Sampling Information

Predose; postdose: 15 and 30 m, 1, 1.5, 2, 4, 6, 12 and 24 h

Drug or Natural Product Administration

Object Administration — n-desmethylclobazam

Oral

Not stated

Not stated

Not stated

31 d

Precipitant Administration — cannabidiol (cbd)

Oral

Solution

20 mg/kg

BID

31 d

Natural Product Characteristics

Not stated

10-day titration, 21 days at maintenance dose of 20 mg/kg/day