In Vitro Enzyme Inhibition Experiment

2C8 Inhibition by Ethanolic GS Extract

Inhibition was detected.  Cutoff used — not specified

paclitaxel

6-alpha-Hydroxy paclitaxel

  • CYP2C8 4306333

Cell fraction Pooled human liver microsomes -7999662

Results

Estimate Fig 1 at 20 μM

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

In-house preparation

HHM-247 and HHM-258

15 min

NADPH

10 min

No NADPH with precipitant

1 or 20 μM