- Natural product: Kratom (Mitragyna speciosa)
- Associated study: Evaluation of the Effects of Mitragyna speciosa Alkaloid Extract on Cytochrome P450 Enzymes Using a High Throughput Assay
In Vitro Enzyme Inhibition Experiment
Mitragynine inhibition of CYP2C19
Inhibition was detected. Cutoff used —
- CYP2C19 4311137
Recombinant expression system Not available
Cytochrome B5 Not available
IC50 was not determined because inhibition was < 50%.
Tranylcypromine was used as a positive control.
(Table 2, Figure 2)
|Sample||Compound measured||Value||Measurement||Study sequence||Additional information||N replicates|
NADPH regenerating system