- Natural product: Cannabis (Cannabis sativa)
- Associated study: Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6.
In Vitro Enzyme Inhibition Experiment
Recombinant: CBDV-AMMC
Inhibition was detected. Cutoff used — Not specified
- CYP2D6 4173631
Recombinant expression system Baculovirus-insect cells
Cytochrome B5 No
Results
Figure 5
Figure 4E
- Ki at log(-4.4) (concentration estimated)
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
2pmol
Commercially available
200 μL
30 min
MgCl2
NADPH regenerating system
0.24-15 μM
5 min
NADPH with precipitant