Evaluation of Time Dependent Inhibition of CYP2A6 by 2-methoxycinnamaldehyde (Model 1) CSV JSON

In Vitro Enzyme Inhibition Experiment

Evaluation of Time Dependent Inhibition of CYP2A6 by 2-methoxycinnamaldehyde (Model 1)

Inhibition was detected.  Cutoff used —

No cutoff was mentioned by the research organization. 

nicotine

cotinine

  • CYP2A6 4309826

Cell fraction Pooled human liver microsomes -7999662

This experiment refers to the MIC-M-IL Model 1 in Table 3.

Results

*not specified in paper whether geometric or arithmetic mean was used - assumed geometric

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

1 uM

Commercially available

10 uL

0-90 min

NADPH regenerating system

Not available

Not available

75 uM

No NADPH with precipitant

190 uL

10 min

0, 5, 10, 20, 40, 80, 100, 125, 150, 175, 200, 250 uM