BCRP inhibition measured by accumulation CSV JSON

In Vitro Transporter Kinetics Experiment

BCRP inhibition measured by accumulation

Transport Activity was detected.  Cutoff used — not specified

mitoxantrone

  • BCRP (ABCG2)

Transfected / siRNA knock-out / injected cells HEK293 transfected cells

Results

Table 1 - Values are expressed as percentage of control, mean ± SEM, n ≥ 4 for mitoxantrone accumulation

Sample Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

Cell Culture Conditions

7 x 10^5 cells/mL

200 μg/mL

Assay Conditions

90 min

37 deg C

5 μM