CBD effect on CLB and N-desmethylclobazam CSV JSON

In Vivo Interaction Study

CBD effect on CLB and N-desmethylclobazam

Increased systemic exposure was detected.

clobazam

cannabidiol (CBD)

Study GWEP1543

Results

Clobazam exposure was increased slightly (~20%) by co-administration with CBD while exposure to the n-desmethylclobazam metabolite was increased by 3.4 fold as a result of concommitant CBD.

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

Fixed-sequence
Parallel
Multiple dosing

Population

Females
Healthy volunteers
Males

12

Arm 1, Group 1

Drug or Natural Product Administration

Object Administration — clobazam

Oral

Not specified

10 mg

5 mg BID

14 days

Precipitant Administration — cannabidiol (CBD)

Oral

Solution

1500 mg

750 mg BID

14 days

Natural Product Characteristics

Not specified