In Vivo Interaction Study
CBD effect on CLB and N-desmethylclobazam
Increased systemic exposure was detected.
Clobazam exposure was increased slightly (~20%) by co-administration with CBD while exposure to the n-desmethylclobazam metabolite was increased by 3.4 fold as a result of concommitant CBD.
|Compound measured||Measurement||Value||Study sequence||Additional information||N replicates|
Arm 1, Group 1
Drug or Natural Product Administration
5 mg BID
750 mg BID