In Vitro Enzyme Inhibition Experiment

Inhibition of CYP2D6 by Licochalcone A

Inhibition was detected.  Cutoff used —

> 25 µg/ml

dextromethorphan 1119510

licochalcone a

dextrorphan 4349487

  • CYP2D6 4173631

Cell fraction Pooled human liver microsomes -7999662

Results

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.2 mg/mL

10 min

NADPH

2.5 μM

11 concentrations from 0.005–250 μg/mL