Mitragynine p-gp transport kinetics MDCK CSV JSON

In Vitro Transporter Kinetics Experiment

Mitragynine p-gp transport kinetics MDCK

No Transport Activity was detected.  Cutoff used — ER of 2

mitragynine

  • P-gp (ABCB1)

Transfected / siRNA knock-out / injected cells MDCK transfected cells

Results

ER for 10 uM also 1.1
(Table 4)

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

Cell Culture Conditions

70 000 cells/well

200 μL

Transwell

2

30–42

Viability and Function

>1100 ohm/cm2

TEER measurements and Ly permeability.

Assay Conditions

120 min

37 deg C

7.4

5,10 uM