- Natural product: Cannabis (Cannabis sativa)
- Associated study: Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study.
In Vitro Transporter Inhibition Experiment
BeWo: CBD-mitoxantrone
Inhibition was detected. Cutoff used —
Not specified
- BCRP (ABCG2)
Cell system BeWo
Results
Figure 1a at 25 μM CBD
10 μM CBD ~130% ± 15% inhibition
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
15 x 10^4 - 20 x 10^4 cells/well
6-well plates
30 min pre-, 30 min post
7.4
10 and 20 μM
The Hebrew University