In Vitro Transporter Inhibition Experiment

MCF7/P-gp: CBD-mitoxantrone

Inhibition was detected.  Cutoff used — Not specified

mitoxantrone

cannabidiol (cbd)

  • P-gp (ABCB1)

Cell system Other cells

Results

Fig 1c at 20 μM CBD
10 μM CBD ~140% ± 20% inhibition

Table 1

Sample Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

Cell Culture Conditions

15 x 10^4 - 20 x 10^4 cells/well

6-well plates

Assay Conditions

30 min pre-, 30 min post

7.4

10 and 25 μM

The Hebrew University