6-alpha-OH-CBD-ketoconazole CSV JSON

In Vitro Enzyme Inhibition Experiment

6-alpha-OH-CBD-ketoconazole

Inhibition was detected.  Cutoff used — Not specified

cannabidiol (CBD)

ketoconazole

6α-OH-cannabidiol

  • CYP3A4 4306811

Recombinant expression system Baculovirus-insect cells
Cytochrome B5 Not available

Results

Table 4 (100-(residual activity (% of control))

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

In-house preparation

0.5 mL

20 min (60 min for recombinant CYP isoforms)

MgCl2
NADPH regenerating system

6.4 μM

1 μM