- Natural product: Cannabis (Cannabis sativa)
- Associated study: Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol
In Vitro Enzyme Inhibition Experiment
Inhibition was detected. Cutoff used — Not specified
- CYP1A1 4173297
Recombinant expression system Baculovirus-insect cells
Cytochrome B5 Not available
%inhibitionpre-incubation at estimated 50 μM at 20 min (Figure 2).
IC50pre-incubation at 0 min (Table 1)
IC50pre-incubation at 20 min - 7.68
Kinact/KI converted from /min/mmol to /min/μM (Table 2)
All other values from Table 2.
|Sample||Compound measured||Value||Measurement||Study sequence||Additional information||N replicates|
NADPH with precipitant