- Natural product: Kratom (Mitragyna speciosa)
- Associated study: Evaluation of the Effects of Mitragyna speciosa Alkaloid Extract on Cytochrome P450 Enzymes Using a High Throughput Assay
In Vitro Enzyme Inhibition Experiment
Mitragynine inhibition of CYP2D6
Inhibition was detected. Cutoff used —
Not specified
- CYP2D6 4173631
Recombinant expression system Not available
Cytochrome B5 Not available
Results
Quinidine was used as the positive control
(Table 2, Figure 2)
Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
---|
Experimental Conditions
1.5 µM
Commercially available
30 min
NADPH regenerating system