In Vitro Enzyme Inhibition Experiment

HLM-CBD

Inhibition was detected.  Cutoff used — Not specified

diltiazem

cannabidiol (CBD)

N-Demethyldiltiazem

  • CYP3A

Cell fraction Individual human liver microsomes

Results

Table 2, Table 3

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

50 μg

Commercially available

200 μL

15 min

MgCl2
NADPH regenerating system

50 μM

NADPH with precipitant

0-50 μM