- Natural product: Cannabis (Cannabis sativa)
- Associated study: Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes
In Vitro Enzyme Inhibition Experiment
6-alpha-OH-CBD-omeprazole
Inhibition was detected. Cutoff used — Not specified
- CYP2C19 4311137
Recombinant expression system Baculovirus-insect cells
Cytochrome B5 Not available
Results
Table 4 (100-(residual activity (% of control))
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
In-house preparation
0.5 mL
20 min (60 min for recombinant CYP isoforms)
MgCl2
NADPH regenerating system
6.4 μM
5 μM