Shrubby sophora (Sophora flavescens)

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Latin Binomial: Sophora flavescens
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Natural Product Information From GSRS

Resource Identifier
= Induction
= Inhibition
= No overall effect
ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-l6H7hA Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR Sophora Flavescens - Effect on PXR Activation in DPX2 Cells Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
sophora flavescens
NPDI-ytkNzA Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR Matrine - Effect on PXR Activation Experiment - 3 In Vitro Nuclear Receptor Induction negative — In Vitro Nuclear Receptor Non-induction
  • Pregnane X receptor (PXR)
matrine
NPDI-KccbZQ Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR Tetrandrine - Effect on PXR Activation Experiment - 1 In Vitro Nuclear Receptor Induction negative — In Vitro Nuclear Receptor Non-induction
  • Pregnane X receptor (PXR)
tetrandrine
NPDI-UIkeTg Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR Oxymatrine - Effect on PXR Activation Experiment - 2 In Vitro Nuclear Receptor Induction negative — In Vitro Nuclear Receptor Non-induction
  • Pregnane X receptor (PXR)
oxymatrine
NPDI-dIRh5Q Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR N-methylcytisine - Effect on PXR Activation Experiment - 4 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • Pregnane X receptor (PXR)
n-methylcytisine
NPDI-KG9M2g Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR Sophocarpine - Effect on PXR Activation Experiment - 5 In Vitro Nuclear Receptor Induction negative — In Vitro Nuclear Receptor Non-induction
  • Pregnane X receptor (PXR)
sophocarpine
NPDI-vhDPDg Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR Sophoranol - Effect on PXR Activation Experiment - 6 In Vitro Nuclear Receptor Induction negative — In Vitro Nuclear Receptor Non-induction
  • Pregnane X receptor (PXR)
sophoranol
NPDI-VDv5UA Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR Allomatrine - Effect on PXR Activation Experiment - 7 In Vitro Nuclear Receptor Induction negative — In Vitro Nuclear Receptor Non-induction
  • Pregnane X receptor (PXR)
allomatrine
NPDI-3_AU-Q Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR N-methylcytisine - Effect of Sophora Flavescens and N-Methylcytisine on CYP3A4 in DPX2 Cells Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • CYP3A4
n-methylcytisine
NPDI-3jqrbg Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR Sophora Flavescens - Effect of Sophora Flavescens 5 g/L and N-Methylcytisine on CYP3A4 in DPX2 Cells Experiment - 2 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • CYP3A4
sophora flavescens
NPDI-DJBgHg Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR Sophora Flavescens - Effect of Sophora Flavescens 1 g/L and N-Methylcytisine on CYP3A4 in DPX2 Cells Experiment - 3 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • CYP3A4
sophora flavescens
NPDI-2Jtpug Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR Sophora Flavescens - Effect of Sophora Flavescens 0.5 g/L and N-Methylcytisine on CYP3A4 in DPX2 Cells Experiment - 4 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • CYP3A4
sophora flavescens
NPDI-DaTCfg Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR N-methylcytisine - Effect of Sophora Flavescens and N-Methylcytisine on CYP3A4 in HepaRG Cells Experiment - 1 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • CYP3A4
n-methylcytisine
NPDI-COzHAQ Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR Sophora Flavescens - Effect of Sophora Flavescens 0.5 g/L and N-Methylcytisine on CYP3A4 in HepaRG Cells Experiment - 2 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • CYP3A4
sophora flavescens
NPDI-4_VbMg Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR Oxymatrine - Pretreatment of Sophora Flavescens and Constituents on CYP3A4 in DPX2 Cells Experiment - 1 In Vitro Nuclear Receptor Induction negative — In Vitro Nuclear Receptor Non-induction
  • CYP3A4
oxymatrine
NPDI-ITjgfQ Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR N-methylcytisine - Pretreatment of Sophora Flavescens and Constituents on CYP3A4 in DPX2 Cells Experiment - 2 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • CYP3A4
n-methylcytisine
NPDI-SFzJpg Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR Sophocarpine - Pretreatment of Sophora Flavescens and Constituents on CYP3A4 in DPX2 Cells Experiment - 3 In Vitro Nuclear Receptor Induction negative — In Vitro Nuclear Receptor Non-induction
  • CYP3A4
sophocarpine
NPDI-cw3k7g Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR Sophoranol - Pretreatment of Sophora Flavescens and Constituents on CYP3A4 in DPX2 Cells Experiment - 4 In Vitro Nuclear Receptor Induction negative — In Vitro Nuclear Receptor Non-induction
  • CYP3A4
sophoranol
NPDI-N3gejQ Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR Allomatrine - Pretreatment of Sophora Flavescens and Constituents on CYP3A4 in DPX2 Cells Experiment - 5 In Vitro Nuclear Receptor Induction negative — In Vitro Nuclear Receptor Non-induction
  • CYP3A4
allomatrine
NPDI-WjNEBg Shrubby sophora (Sophora flavescens) Chinese Herbal Medicine Sophora Flavescens Activates PXR Sophora Flavescens - Pretreatment of Sophora Flavescens and Constituents on CYP3A4 in DPX2 Cells Experiment - 6 In Vitro Nuclear Receptor Induction positive — In Vitro Nuclear Receptor Induction
  • CYP3A4
sophora flavescens